HOW TO STOP THE SPREADING OF SUPER BACTERIA?

Autores

  • Mishell Poleth Ortiz Jacome School of Biological Sciences and Engineering, Yachay Tech University
  • Fernando A. Gonzales-Zubiate YACHAY TECH UNIVERSITY

Palavras-chave:

Antimicrobial resistance, antibiotics, Beta-lactamase, ESBL

Resumo

According to the World Health Organization (WHO), the number of antibiotic-resistant bacteria has increased exponentially, currently causing about 700,000 deaths each year. The exaggerated use of antibiotics used in the treatment of human and veterinary infections has contributed to the appearance and spread of multidrug resistant strains, making antibiotics obsolete and contributing to the unfavorable prognosis of several infections. Present day, the most critical problem for public health is the growing number of bacteria resistant to Beta-lactam antibiotics such as penicillins, cephalosporins, cepamycin and carbapenems, widely used in human and veterinary medicine. In fact, enterobacteria producing extended-spectrum Beta-lactamase (ESBL) have been classified as critical priority pathogens by WHO. In this review, we will explain the mechanisms of antimicrobial resistance and discuss potential solutions to prevent further spread.

Biografia do Autor

Mishell Poleth Ortiz Jacome, School of Biological Sciences and Engineering, Yachay Tech University

Student at School of Biological Sciences and Engineering, Yachay Tech University

Fernando A. Gonzales-Zubiate, YACHAY TECH UNIVERSITY


Dr. Gonzales-Zubiate obtained a bachelor degree in Biology at Federico Villarreal University from Peru. He did his master and doctoral studies in Biochemistry at University of São Paulo, during that time he studied ribosomal RNA processing in the yeast Saccharomyces cerevisiae. Years later, being a postdoc at the University of California – Los Angeles (UCLA), he studied the function of proteins involved in pseudouridylation of rRNA. Continuing his research, as postdoc at University of Aarhus in Denmark, he studied the mechanisms involved in the maturation of mRNAs and their transport to the cytoplasm. Back to Brazil, he started a postdoc at the University of São Paulo developing the research project «Biochemical and Structural Characterization of yeast Exosome Interactions with regulatory proteins of its activity”. At the present time, he hold a position of Researcher Professor at School of Biological Sciences and Engineering at University of Science and Technology Yachay Tech in Ecuador. His research is focused in studying mechanisms of nucleus/cytoplasm transport and how failures would lead to affect more complex processes in the cell and consequently severe diseases in humans (cell hypertrophy, angiogenesis, atherosclerosis, hypertension, cancer, viral infection and diabetes). Through the study of transport of key proteins in these diseases, it will be determined the mechanisms that cause a specific disease and in the future and elucidate a possible therapeutic treatment focused on this pathway.

Referências

ALI J, RAFIQ QA, AND RATCLIFFE E (2018). Antimicrobial resistance mechanisms and potential synthetic treatments. Future Science OA, 4(4), FSO290.

ALÓS JI (2015). Resistencia bacteriana a los antibióticos: una crisis global. Enfermedades Infecciosas y Microbiología Clínica, 33(10), 692–699.

https://doi.org/10.1016/j.eimc.2014.10.004

ASLAM B, KHURSHID M, MUZAMMIL S, RASOOL MH, NISAR MA, ALVI RF, AND BALOCH Z (2018). Antibiotic resistance: a rundown of a global crisis. Infection and Drug Resistance, 11, 1645–1658.

https://doi.org/10.2147/IDR.S173867

BAKER SJ, PAYNE DJ, RAPPUOLI R, AND DE GREGORIO E (2018). Technologies to address antimicrobial resistance. Proceedings of the National Academy of Sciences, 115(51), 12887–12895.

https://doi.org/10.1073/pnas.1717160115

HOLMES RK, JOBLING MG (1996). BARON S, ET AL. (eds.). [5196190145103398 Genetics: Conjugation. in: Baron's Medical Microbiology] Check |url= value (help) (4th ed.). Univ of Texas Medical Branch.

KOONIN EV, MAKAROVA KS, ARAVIND L (2001). "Horizontal gene transfer in prokaryotes: quantification and classification". Annu. Rev. Microbiol. 55 (1): 709–42. doi:10.1146/annurev.micro.55.1.709. PMC 4781227. PMID 11544372.

ORTEGA MS (2017). Determinación de Beta-lactamasas de Espectro Extendido en Escherichia coli y Klebsiella pneumoniae a través de pruebas moleculares en urocultivos provenientes de pacientes ambulatorios con infecciones de vías urinarias Mayra Sofía Ortega Ortega Mayra Sofí, 61.

PHILLIPS I, CASEWELL M, COX T, GROOT B, FRIIS C, JONES R, NIGHTINGALE CH, PRESTON R, AND WADDELL J. Does the use of antibiotics in food animals pose a risk to human health? A critical review of published dataJ. Antimicrob. Chemother. (2004) 53 (1): 28-52. doi: 10.1093/jac/dkg483

QUIÑONES D (2017). Resistencia antimicrobiana: evolución y perspectivas actuales ante el enfoque “Una

salud”. Revista Cubana de Medicina Tropical, 69(3), 1–17. Retrieved from http://scielo.sld.cuhttp//scielo.sld.cu

QUIZHPE A, MURRAY M, MUÑOZ G, PERALTA J, AND CALLE K (2011). Recuperar la salud integral y la armonía de los ecosistemas, para contener la resistencia bacteriana a los antibióticos. Cuenca: ReAct Latinoamérica, (c), 2–6.

REACTGROUP https://www.reactgroup.org/about-us/a-global-network/react-latin-america/

ROSDAHL VK, PEDERSEN KB. The Copenhagen Recommendations. Report from the Invitiational EU Conference on The Microbial Threat. Ministry of Health, Ministry of Food, Agriculture and Fisheries, Denmark. 2002:1-52. http://www.sum.dk/

SILVA-CEVALLOS J, MONTALVO A, MARTÍNEZ R, PALMA R, AND DELGADO A (2012). En Infecciones Hospitalarias y Adquiridas Autores : Revista de Investigación Científica, 9–19.

SMITH DL, HARRIS AD, JOHNSON JA, SILBERGELD EK, AND MORRIS JG. Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria Biological Sciences. PNAS 2002. 99 (9) 6434-6439; published ahead of print April 23, 2002, doi:10.1073/pnas.082188899

SOUTHWICK FS (2008). Infectious diseases : a clinical short course. McGraw-Hill Medical.

Transduction, Genetic at the US National Library of Medicine Medical Subject Headings (MeSH)

WORTHINGTON RJ, MELANDER C (2013). Overcoming resistance to ?-lactam antibiotics. J Org Chem. 2013 May 3;78(9):4207-13. doi: 10.1021/jo400236f. Epub 2013 Mar 28. Review.

World-Health-Organization/Home/Newsroom/Fact sheets/Detail/Antimicrobial resistance (https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance).

World-Health-Organization/Home/Emergencies/Ten threats to global health in 2019 (https://www.who.int/emergencies/ten-threats-to-global-health-in-2019).

ZAMAN SB, HUSSAIN MA, NYE R, MEHTA V, MAMUN KT, AND HOSSAIN N (2017). A Review on Antibiotic Resistance: Alarm Bells are Ringing. Cureus, 9(6). https://doi.org/10.7759/cureus.1403

Downloads

Publicado

10-10-2019

Edição

v. 7 n. 1 (2019): Anais do VII Seminário Internacional Étnico Racial

Seção

Evento: Seminário Étnico-Racial

Licença

1 - Os textos publicados na revista são de inteira responsabilidade de seus autores.

2 - É permitida a reprodução, desde que citada a fonte e o autor.

 Após o artigo aprovado, o autor principal deverá enviar declaração, conforme o modelo:

AUTORIZAÇÃO PARA PUBLICAÇÃO

(Nome do autor), portador do documento de identidade nº ________ (no caso de vários autores citar todos),  autorizo ( ou autorizam, no caso de diversos autores) a publicação do artigo (nome do artigo), com exclusividade pela Revista Eniac Pesquisa, em meio eletrônico.

A contribuição é original e inédita, e não está sendo avaliada para publicação por outra revista; caso contrário, deve-se justificar em "Comentários ao editor".

Dados de todos os autores:

Nome completo:

Instituição:

E-mail:

Telefone:

Obs.: Informar os códigos dos serviços DDD e DDI.

Assinatura do autor principal: ____________________________________