Mishell Poleth Ortiz Jacome, Fernando A. Gonzales-Zubiate


According to the World Health Organization (WHO), the number of antibiotic-resistant bacteria has increased exponentially, currently causing about 700,000 deaths each year. The exaggerated use of antibiotics used in the treatment of human and veterinary infections has contributed to the appearance and spread of multidrug resistant strains, making antibiotics obsolete and contributing to the unfavorable prognosis of several infections. Present day, the most critical problem for public health is the growing number of bacteria resistant to Beta-lactam antibiotics such as penicillins, cephalosporins, cepamycin and carbapenems, widely used in human and veterinary medicine. In fact, enterobacteria producing extended-spectrum Beta-lactamase (ESBL) have been classified as critical priority pathogens by WHO. In this review, we will explain the mechanisms of antimicrobial resistance and discuss potential solutions to prevent further spread.


Antimicrobial resistance, antibiotics, Beta-lactamase, ESBL

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