• Mishell Poleth Ortiz Jacome School of Biological Sciences and Engineering, Yachay Tech University
  • Fernando A. Gonzales-Zubiate YACHAY TECH UNIVERSITY


Antimicrobial resistance, antibiotics, Beta-lactamase, ESBL


According to the World Health Organization (WHO), the number of antibiotic-resistant bacteria has increased exponentially, currently causing about 700,000 deaths each year. The exaggerated use of antibiotics used in the treatment of human and veterinary infections has contributed to the appearance and spread of multidrug resistant strains, making antibiotics obsolete and contributing to the unfavorable prognosis of several infections. Present day, the most critical problem for public health is the growing number of bacteria resistant to Beta-lactam antibiotics such as penicillins, cephalosporins, cepamycin and carbapenems, widely used in human and veterinary medicine. In fact, enterobacteria producing extended-spectrum Beta-lactamase (ESBL) have been classified as critical priority pathogens by WHO. In this review, we will explain the mechanisms of antimicrobial resistance and discuss potential solutions to prevent further spread.

Biografia do Autor

Mishell Poleth Ortiz Jacome, School of Biological Sciences and Engineering, Yachay Tech University

Student at School of Biological Sciences and Engineering, Yachay Tech University

Fernando A. Gonzales-Zubiate, YACHAY TECH UNIVERSITY

Dr. Gonzales-Zubiate obtained a bachelor degree in Biology at Federico Villarreal University from Peru. He did his master and doctoral studies in Biochemistry at University of São Paulo, during that time he studied ribosomal RNA processing in the yeast Saccharomyces cerevisiae. Years later, being a postdoc at the University of California – Los Angeles (UCLA), he studied the function of proteins involved in pseudouridylation of rRNA. Continuing his research, as postdoc at University of Aarhus in Denmark, he studied the mechanisms involved in the maturation of mRNAs and their transport to the cytoplasm. Back to Brazil, he started a postdoc at the University of São Paulo developing the research project «Biochemical and Structural Characterization of yeast Exosome Interactions with regulatory proteins of its activity”. At the present time, he hold a position of Researcher Professor at School of Biological Sciences and Engineering at University of Science and Technology Yachay Tech in Ecuador. His research is focused in studying mechanisms of nucleus/cytoplasm transport and how failures would lead to affect more complex processes in the cell and consequently severe diseases in humans (cell hypertrophy, angiogenesis, atherosclerosis, hypertension, cancer, viral infection and diabetes). Through the study of transport of key proteins in these diseases, it will be determined the mechanisms that cause a specific disease and in the future and elucidate a possible therapeutic treatment focused on this pathway.


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Evento: Seminário Étnico-Racial